Refining the Role of Lgl, Dlg and Scrib in Tumor Suppression and Beyond: Learning from the Old Time Classics
نویسندگان
چکیده
Fani Papagiannouli1 and Bernard M. Mechler2,3,4 1Cell Networks–Cluster of Excellence, Centre for Organismal Studies (COS) and BIOQUANT Center, University of Heidelberg, Heidelberg, 2Department of Cell Biology, Institute of Physiology, 1st Faculty of Medicine, Charles University, Prague, 3Deutsches Krebsforschungszentrum, Heidelberg, 4VIT-University, Vellore, Tamil Nadu, 1,3Germany 2Czech Republic 4India
منابع مشابه
The internal structure of embryonic gonads and testis development in Drosophila melanogaster requires scrib, lgl and dlg activity in the soma.
Interest in the mechanism leading to the formation of the germline and its differentiation during Drosophila development, initiated even as soon as the first ever cloned tumour suppressor gene in Drosophila, the lethal (2) giant larvae (lgl), had been identified. Further work has shown that the lgl, as well as discs large-1 (dlg) and scribble (scrib) tumor suppressor genes code for scaffolding ...
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